Reiko Okano comes from Ibaraki Prefecture. She had her debut in 1982 with Esther, Please. Well-known manga comics which she has created are Fancy Dance, Onmyoji (adapted from the novel by Baku Yumemakura) and Onmyoji: Tamatebako (adapted from the novel by Baku Yumemakura).
In addition, she has produced the belly dancing femininity motif-inspired Inanna, Ryogoku-Oshare-Rikishi, Yomi Henjo Yawa and Calling (adapted from the novel The Forgotten Beasts of Eld, by Patricia Ann Mckillip). 　　　　　　　　　　　　　　　　　　　　　　　　　　
She has also released music-related works, including a Music for Onmyoji (Brian Eno/Reigakusha Ensemble), which she produced as a concept album for the Onmyoji manga, Kizui (Japan Traditional Cultures Foundation), EYE MOON by theremin musician Yano Yuki and the albumPhantasmagoria by Ichiko Hashimoto.
Following the Great East Japan Earthquake, Okano took part in the “Ogatsuhoin Kagura (Ogatsuhoin ceremonial dance)” support campaign which was carried out to provide help with rebuilding efforts in Ogatsu Town, which is part of Ishinomaki City in Miyagi Prefecture. (The town was fully rebuilt in 2015.)
Okano is also a practitioner of Crystalline Soul Healing.